Risk factors for the development of posttraumatic hydrocephalus after unilateral decompressive craniectomy in

Tsung-Ming Su1, Chu-Mei Lan2, Tsung-Han Lee1

  • 1Department of Neurosurgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, No. 123 Dapi Road, Niaosong District, Kaohsiung City 83301, Taiwan.

Insights

Older age and contralateral subdural hygroma (SDG) increase the risk of posttraumatic hydrocephalus (PTH) after decompressive craniectomy (DC) for traumatic brain injury (TBI). Early detection and management are crucial for these patients.

Area of Science:

  • Neurosurgery
  • Trauma Surgery
  • Neurology

Background:

  • Decompressive craniectomy (DC) is increasingly used for refractory intracranial hypertension in traumatic brain injury (TBI).
  • Complications of DC include subdural hygroma (SDG) and posttraumatic hydrocephalus (PTH).

Purpose of the Study:

  • To investigate the incidence and risk factors of PTH after unilateral DC in TBI patients.
  • To explore the relationship between SDG types and PTH development.

Main Methods:

  • Retrospective analysis of 143 TBI patients undergoing unilateral DC.
  • Stepwise logistic regression to identify independent risk factors for PTH.

Main Results:

  • PTH incidence was 30.1%.
  • Independent risk factors for PTH were older age (OR=1.036) and contralateral SDG (OR=5.613).
  • PTH was associated with significantly unfavorable outcomes (p < 0.0001).

Conclusions:

  • Older TBI patients with contralateral SDG after unilateral DC require close surveillance for early PTH detection.
  • Timely management of PTH is essential for improving outcomes in TBI patients.

Related Concept Videos

Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.4K
Factors Affecting Protein-Drug Binding: Patient-Related Factors01:29

Factors Affecting Protein-Drug Binding: Patient-Related Factors

Protein-drug binding, a pivotal aspect of pharmacokinetics, is subject to considerable variability influenced by an array of patient-related factors. The intricate interplay of age, individual differences, and pathological conditions significantly impact the binding dynamics and subsequent pharmacological effects.
Age stands as a key determinant in protein-drug binding. Neonates, characterized by low albumin content, experience heightened concentrations of unbound drugs such as phenytoin and...
322
Pathophysiology of Peptic Ulcer Disease: Injurious Factors01:22

Pathophysiology of Peptic Ulcer Disease: Injurious Factors

Peptic ulcers are sores on the stomach's inner lining and the upper small intestine, which are the result of disruptions in the mucosal layer that houses parietal cells which produce gastric acid, and chief cells which secrete pepsinogen.
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds...
1.2K
Transcription Factors02:16

Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
82.7K
Traumatic Memory01:20

Traumatic Memory

Emotionally traumatic events often lead to memories that are exceptionally vivid and enduring, sometimes persisting with remarkable clarity throughout an individual's life. A classic example of this phenomenon is a person who survives a car accident. Even years later, they may recall every detail of the event with startling accuracy — the screeching of the tires, the jarring impact, and the acrid smell of burning rubber. Such vividness contrasts sharply with how an individual...
569
Relative Risk01:12

Relative Risk

Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
2.1K