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Genetic differences between C57BL/6 substrains affect the process of testis differentiation in YPOS mice
Toshifumi Yokoyama1, Yuuka Miura1, Anzu Yamamoto1
1Department of Animal Science, Graduate School of Agricultural Science, Kobe University, 1-1 Rokkodai, Nada-ku, Kobe, Hyogo 657-8501, Japan.
The Journal of Veterinary Medical Science
|March 5, 2019
Summary
Genetic background influences sex development in mice. The C57BL/6J substrain significantly perturbs testicular differentiation, highlighting the importance of genetic substrain differences in research.
Area of Science:
- Genetics
- Developmental Biology
- Mammalian Reproduction
Background:
- C57BL/6J-XY POS (B6J-XYPOS) mice possess a Y chromosome from Mus musculus poschiavinus on a C57BL/6J genetic background, typically developing ovotestes or ovaries.
- Previous studies involving a C57BL/6N background in XYPOS mice revealed the appearance of testes alongside ovaries or ovotestes.
Purpose of the Study:
- To investigate the specific influence of the C57BL/6J genetic background on testicular differentiation.
- To determine if reintroducing the C57BL/6J genetic background into B6N-XYPOS mice alters sex development outcomes.
Main Methods:
- Genetic background manipulation in XYPOS mice.
- Comparative analysis of gonadal development (ovaries, ovotestes, testes) across different mouse substrains.
Main Results:
- Reintroducing the C57BL/6J genetic background into B6N-XYPOS mice significantly reduced the incidence of testes.
- Only ovaries developed in mice with the recovered C57BL/6J genetic background.
- The C57BL/6J substrain appears to perturb the testicular differentiation process.
Conclusions:
- Substrain differences within C57BL mice are critical and can significantly impact sex development.
- The C57BL/6J genetic background plays a crucial role in suppressing or perturbing testicular differentiation in XYPOS mice.
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