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[On-line Adaptive Radiotherapy Using MRI-Guided Technique].

Hiroyuki Okamoto1, Tatsuya Sakasai2, Shie Nishioka1

  • 1Department of Medical Physics, National Cancer Center Hospital.

Igaku Butsuri : Nihon Igaku Butsuri Gakkai Kikanshi = Japanese Journal of Medical Physics : an Official Journal of Japan Society of Medical Physics
|March 5, 2019
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Summary

This study details the commissioning of the MRIdian MRI-guided radiotherapy system for online adaptive radiotherapy (ART). It also describes patient-specific quality assurance (QA) methods developed for this advanced cancer treatment approach.

Keywords:
IMRTMRIMRI-guidedadaptive radiotherapy

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Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Radiotherapy Technology

Background:

  • The introduction of MRI-guided radiotherapy systems enables real-time tumor monitoring and adaptive treatment planning.
  • Online adaptive radiotherapy (ART) offers improved tumor coverage and organ sparing during cancer treatment.

Purpose of the Study:

  • To summarize the commissioning process of the MRIdian MRI-guided radiotherapy system.
  • To describe the established patient-specific quality assurance (QA) protocols for online ART.

Main Methods:

  • Installation and configuration of the MRIdian system, featuring three 60Co sources and a 0.35 T MRI.
  • Real-time tumor tracking using Cine-MRI for treatment gating and adaptive adjustments.
  • Development and implementation of patient-specific QA procedures for online ART.

Main Results:

  • Successful commissioning of the MRIdian system for online ART delivery.
  • Established patient-specific QA procedures to address limitations in online ART.
  • Demonstrated feasibility of real-time tumor monitoring and adaptive radiotherapy.

Conclusions:

  • The MRIdian system facilitates advanced online ART with real-time adaptive capabilities.
  • Patient-specific QA is crucial for ensuring the safety and efficacy of online ART.
  • This work provides a framework for implementing and validating MRI-guided adaptive radiotherapy.