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Th2 and Th17 Induce Dry Skin in a Mouse Model of Arthritis

Kenji Goto1,2, Keiichi Hiramoto2, Kazuya Ooi1,2

  • 1Laboratory of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science.

Biological & Pharmaceutical Bulletin
|March 5, 2019
PubMed

Insights

Rheumatoid arthritis (RA) can cause dry skin. This study found that T helper 2 (Th2) and T helper 17 (Th17) cells contribute to RA-induced skin dryness through distinct inflammatory pathways.

Area of Science:

  • Immunology
  • Dermatology
  • Rheumatology

Background:

  • Skin dryness is a common symptom in rheumatoid arthritis (RA) mouse models.
  • The specific immunological mechanisms driving RA-associated skin dryness remain largely unknown.
  • T helper (Th)2 and Th17 cells are implicated in various autoimmune conditions.

Purpose of the Study:

  • To investigate the role of Th2 and Th17 cells in the development of dry skin in a collagen-induced arthritis (CIA) mouse model.
  • To elucidate the distinct mechanisms by which Th2 and Th17 cells contribute to skin barrier dysfunction in RA.

Main Methods:

  • Utilized a DBA/1JJmsSlc mouse model of collagen-induced arthritis.
  • Administered specific inhibitors targeting Th2 or Th17 cells.
  • Evaluated transepidermal water loss (TEWL) as a measure of skin barrier function.
  • Assessed plasma levels of key inflammatory markers including thymic stromal lymphopoietin, IL-6, IL-17, and TNF-α.

Main Results:

  • Arthritic mice exhibited significantly increased TEWL and elevated levels of IL-6, IL-17, and TNF-α compared to controls.
  • Th2 cell inhibition normalized TEWL and reduced IL-6 and TNF-α levels.
  • Th17 cell inhibition reversed TEWL and decreased IL-17 levels, indicating distinct roles for each T helper cell subset.

Conclusions:

  • Both Th2 and Th17 cells play a significant role in inducing skin dryness in the context of rheumatoid arthritis.
  • These T helper cell subsets mediate skin barrier impairment through partially distinct inflammatory pathways.
  • Targeting Th2 and Th17 cells may offer therapeutic potential for managing skin dryness in RA patients.
Keywords:
T helper 17 cellT helper 2 cellarthritisdendritic celldry skinthymic stromal lymphopoietin

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