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Updated: Jan 28, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
Pleomorphic Mantle Cell Lymphoma of the Tongue Base Presenting With Dysphagia
Marisa A Ryan1,2, Tracy Cheng3, David S Yoo4
1Division of Head and Neck Surgery & Communication Sciences, Department of Surgery, Duke University, Durham, NC, USA.
Objectives:
We aim to increase awareness of pleomorphic mantle cell lymphoma as a rare, but aggressive form of lymphoma with propensity for recurrence in secondary locations.
Methods:
We report the case of a 70-year-old man who presented with chronic post-nasal drainage, dysphagia, and voice changes caused by a tongue base mass.
Results:
Partial excision and pathology showed a pleomorphic mantle cell lymphoma, and radiation treatment was completed. A regional recurrence was detected 3 years later and treated with radiation. He had no evidence of disease 17 months after treatment of the recurrence and is under close surveillance.
Conclusions:
Pleomorphic mantle cell lymphoma is an aggressive subtype of non-Hodgkin lymphoma that can affect the head and neck. Confirming the diagnosis with immunotyping and genotyping from fresh specimens can guide appropriate treatment and then close clinical follow-up.
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