Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

454
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
454
Renal Corpuscle01:20

Renal Corpuscle

7.3K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
7.3K
Renal Clearance01:23

Renal Clearance

2.6K
The glomerular filtration rate (GFR) is a critical marker of kidney function, reflecting the efficiency of filtration by the glomeruli. Renal clearance of specific substances, such as inulin or creatinine, is commonly used to measure GFR.
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
2.6K
Extraction: Advanced Methods00:56

Extraction: Advanced Methods

1.1K
Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
1.1K
Overview of Advanced Functional Groups02:22

Overview of Advanced Functional Groups

29.7K

Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of Advanced Functional Groups
The table below summarizes some of the major functional groups in organic chemistry.
29.7K
Renal Drug Clearance: Comparison Between Renal Excretion Methods01:08

Renal Drug Clearance: Comparison Between Renal Excretion Methods

603
Renal clearance is a critical parameter encompassing kidney filtration, secretion, and reabsorption processes. It is calculated using a specific equation to determine the rate at which the kidneys clear a drug.
Renal clearance is often associated with the renal glomerular filtration rate (GFR), which represents the rate at which plasma is filtered through the glomeruli in the kidney. When drug reabsorption is minimal and there is no active secretion, renal clearance is closely related to the...
603

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficacy of the Self-management Support System DialBetesPlus for Diabetic Kidney Disease: Protocol for a Randomized Controlled Trial.

JMIR research protocols·2021
Same author

Two long-term phase 3 studies of enarodustat (JTZ-951) in Japanese anemic patients with chronic kidney disease not on dialysis or on maintenance hemodialysis: SYMPHONY ND-Long and HD-Long studies.

Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·2021
Same author

Performance evaluation of the new chemiluminescent intact FGF23 assay relative to the existing assay system.

Journal of bone and mineral metabolism·2021
Same author

Clinical Characteristics and Incidences of Benign and Malignant Insulinoma Using a National Inpatient Database in Japan.

The Journal of clinical endocrinology and metabolism·2021
Same author

Aging-Related Kidney Diseases.

Contributions to nephrology·2021
Same author

The Future of Nephrology and Public Health.

Contributions to nephrology·2021

Related Experiment Video

Updated: Jan 28, 2026

Renal Ischaemia Reperfusion Injury: A Mouse Model of Injury and Regeneration
12:27

Renal Ischaemia Reperfusion Injury: A Mouse Model of Injury and Regeneration

Published on: June 7, 2014

51.3K

Recent advances in renal regeneration.

Sho Hasegawa1, Tetsuhiro Tanaka1, Masaomi Nangaku1

  • 1Division of Nephrology and Endocrinology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.

F1000Research
|March 5, 2019
PubMed
Summary

Regenerating complex human kidneys from pluripotent stem cells (PSCs) is difficult. Researchers have successfully induced key kidney cell types from PSCs, enabling in vitro kidney structure reconstruction.

Keywords:
kidneypluripotent stem cellsrenegeration

More Related Videos

Laser Ablation of the Zebrafish Pronephros to Study Renal Epithelial Regeneration
07:27

Laser Ablation of the Zebrafish Pronephros to Study Renal Epithelial Regeneration

Published on: August 29, 2011

15.7K
Direct Drug Delivery to Kidney via the Renal Artery
11:18

Direct Drug Delivery to Kidney via the Renal Artery

Published on: April 17, 2021

8.2K

Related Experiment Videos

Last Updated: Jan 28, 2026

Renal Ischaemia Reperfusion Injury: A Mouse Model of Injury and Regeneration
12:27

Renal Ischaemia Reperfusion Injury: A Mouse Model of Injury and Regeneration

Published on: June 7, 2014

51.3K
Laser Ablation of the Zebrafish Pronephros to Study Renal Epithelial Regeneration
07:27

Laser Ablation of the Zebrafish Pronephros to Study Renal Epithelial Regeneration

Published on: August 29, 2011

15.7K
Direct Drug Delivery to Kidney via the Renal Artery
11:18

Direct Drug Delivery to Kidney via the Renal Artery

Published on: April 17, 2021

8.2K

Area of Science:

  • Stem cell biology
  • Developmental biology
  • Bioengineering

Background:

  • Kidney regeneration from pluripotent stem cells (PSCs) faces challenges due to the organ's intricate structure.
  • The embryonic metanephros comprises three critical progenitor cell types: nephron progenitors, ureteric bud, and stromal progenitors.

Purpose of the Study:

  • To review the progress in inducing renal progenitors from PSCs.
  • To explore advancements in bioengineering and interspecies kidney regeneration for functional kidney reconstruction.

Main Methods:

  • Cell-lineage tracing analysis to understand kidney developmental processes.
  • Induction of nephron progenitors and ureteric bud from PSCs.
  • Reconstruction of three-dimensional (3D) kidney structures in vitro.

Main Results:

  • Successful induction of nephron progenitors and ureteric bud from PSCs.
  • Demonstration of in vitro reconstruction of kidney structures, including glomeruli, renal tubules, and branching ureters.
  • Identification of remaining challenges in inducing stromal progenitors and achieving full kidney maturation.

Conclusions:

  • Further research is needed to induce stromal progenitors and mature reconstructed kidneys for full functionality.
  • Bioengineering techniques like decellularization and 3D bioprinting, alongside insights from other species, offer promising avenues for complex kidney regeneration.
  • Achieving functional kidney regeneration requires addressing the induction of all progenitor types and mastering spatial arrangement, including vascular networks and urinary pathways.