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Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

Published on: February 9, 2011

23.6K

Effects of stigmata maydis on the methicillin resistant Staphylococus aureus biofilm formation

Fei Shang1, Long Li1, Lumin Yu1

  • 1School of Life Sciences, Anhui Agricultural University, Hefei, Anhui, China.

Peerj
|March 5, 2019
PubMed
Abstract

Insights

Corn silk extracts combat chronic mastitis in dairy cows by inhibiting biofilm formation in methicillin-resistant Staphylococcus aureus (MRSA). This natural remedy also enhances vancomycin effectiveness against these difficult-to-treat infections.

Area of Science:

  • Veterinary Medicine
  • Microbiology
  • Pharmacology

Background:

  • Mastitis, a significant dairy farm economic burden, is often caused by Staphylococcus aureus.
  • Biofilm formation by Staphylococcus aureus contributes to chronic mastitis, complicating treatment.
  • Methicillin resistance in Staphylococcus aureus (MRSA) presents a major therapeutic challenge.

Purpose of the Study:

  • To investigate the impact of Stigmata maydis (corn silk) on biofilm formation by MRSA.
  • To assess the effect of Stigmata maydis on vancomycin susceptibility in MRSA strains.

Main Methods:

  • Antibacterial activity assays were conducted.
  • Biofilm formation assays were performed.
  • Real-time reverse transcription PCR was utilized.
  • Experiments focused on MRSA strains from dairy cows with mastitis.

Main Results:

  • Aqueous extracts of Stigmata maydis demonstrated inhibition of MRSA biofilm formation.
  • Corn silk extracts increased vancomycin susceptibility in MRSA strains cultured under biofilm conditions.

Conclusions:

  • Stigmata maydis aqueous extracts effectively inhibit MRSA biofilm formation.
  • Corn silk enhances vancomycin efficacy against MRSA in biofilm states, offering a potential therapeutic strategy.
Keywords:
BiofilmBovine mastitisMRSAStigmata maydisVancomycin

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