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Physiological changes in hemostasis associated with acute exercise.

M E Wheeler, G L Davis, W J Gillespie

    Journal of Applied Physiology (Bethesda, Md. : 1985)
    |March 1, 1986
    PubMed
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    Acute exercise boosts blood clotting factors and fibrinolytic activity. Post-exercise lactate levels correlate with these hemostatic changes, suggesting a common underlying mechanism.

    Area of Science:

    • Exercise Physiology
    • Hemostasis and Thrombosis
    • Biochemistry

    Background:

    • Acute exercise impacts hemostatic variables, including fibrinolytic activity (FA) and factor VIII.
    • The precise mechanisms linking exercise to these hemostatic changes remain unclear.
    • Investigating the role of blood lactate and 2,3-diphosphoglycerate (DPG) is crucial.

    Purpose of the Study:

    • To explore the relationship between exercise-induced changes in blood lactate, DPG, and key hemostatic variables.
    • To identify potential mechanisms underlying exercise-induced alterations in blood coagulation and fibrinolysis.
    • To determine if lactate and high-density lipoprotein (HDL) can predict post-exercise fibrinolytic activity.

    Main Methods:

    • A multistage treadmill protocol was employed to exercise male volunteers to maximal effort.

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  • Blood samples were collected pre-exercise, immediately post-exercise, and 8 minutes post-exercise.
  • Hemostatic variables, blood lactate, DPG, and HDL concentrations were analyzed.

    • Main Results:

    • All measured hemostatic variables significantly increased post-exercise.
    • Peak levels for factor VIII coagulant, factor VIII-related antigen, and factor VIII ristocetin cofactor occurred 8 minutes post-exercise.
    • Post-exercise lactate showed significant correlations with factor VIII coagulant and fibrinolytic activity, further strengthened by pre-exercise HDL levels.

    Conclusions:

    • Exercise-induced increases in hemostatic variables are significant and exhibit a delayed peak.
    • Blood lactate levels post-exercise are strongly associated with changes in factor VIII and fibrinolytic activity.
    • Lactate and pre-exercise HDL may serve as predictors for post-exercise fibrinolytic activity, indicating shared underlying physiological stimuli.