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Antibacterial Prophylaxis in Emergency Surgery of Abdominal Infection
Fariz H Jamalov1, Rauf M Agayev1, Idris T Achundov1
1Department of Surgical Disease, Azerbaijan Medical University, Baku, Azerbaijan.
Euroasian Journal of Hepato-Gastroenterology
|March 5, 2019
Summary
Amoxiclav (amoxicillin/clavulanic acid) prophylaxis reduced postoperative complications in emergency abdominal surgery. This antibiotic regimen led to an 8.1% complication rate, demonstrating its effectiveness.
Area of Science:
- Surgical Infection Prevention
- Pharmacology
- Clinical Microbiology
Background:
- Destructive acute surgical sicknesses of the abdominal cavity necessitate urgent surgical intervention.
- Postoperative purulent-septic complications remain a significant concern in emergency abdominal surgery.
- Effective antibiotic prophylaxis is crucial for reducing morbidity and mortality.
Purpose of the Study:
- To analyze the efficacy of amoxiclav (amoxicillin/clavulanic acid) as preoperative antibiotic prophylaxis in emergency abdominal surgery.
- To compare the outcomes of amoxiclav prophylaxis with cefotaxime and metronidazole in patients undergoing urgent abdominal surgery.
- To evaluate the impact of antibiotic prophylaxis on postoperative purulent-septic complications and the need for re-operation.
Main Methods:
- Retrospective analysis of 148 patients with destructive acute surgical sicknesses of the abdominal cavity.
- Patients were divided into two groups: a basic group receiving 120-hour amoxiclav prophylaxis and a control group receiving 120-hour cefotaxime plus metronidazole prophylaxis.
- Outcomes assessed included the frequency of postoperative purulent-septic complications and recurring operations.
Main Results:
- The group receiving amoxiclav prophylaxis demonstrated a significantly lower frequency of postoperative purulent-septic complications and recurring operations.
- The complication rate in the amoxiclav group was reported at 8.1%.
- This suggests a positive impact of amoxiclav on surgical site infection prevention in this patient cohort.
Conclusions:
- Preoperative antibiotic prophylaxis with amoxiclav is effective in reducing postoperative purulent-septic complications in patients undergoing emergency abdominal surgery.
- Amoxiclav offers a favorable alternative for antibiotic prophylaxis in urgent surgical interventions for abdominal infections.
- The findings support the use of amoxiclav for optimizing surgical outcomes in emergency abdominal procedures.
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