How much medication is delivered in a novel drug delivery technique that uses a tattoo machine?

Even though dermatologists often perform drug delivery procedures, it is necessary to assess their safety.

Quantify the amount of medication delivered using the MMP drug delivery technique and outline other safety parameters.

Using a simple and novel technique, we attempted to quantify the amount of medication delivered by weighing human skin samples before and after delivery.

In drug delivery done on human skin using a liquid with a density of 1,271,460 μg/ml (the values expressed in this manuscript are in µg), a needling density of 570 perforations/cm² , and a needling depth of 300 microns, we estimate that 1,175 μg/cm² were delivered (standard deviation 601 μg/cm² , standard error 190 μg/cm² ).

This result is only applicable to the protocol proposed in this study for the MMP drug delivery technique.

The MMP drug delivery technique injects small amounts of medication (1,175 μg/cm² ) homogeneously into the dermis.