Management of a neonate with diffuse cutaneous mastocytosis: Case report and literature review
Helena A Jenkinson1, Ashley D Lundgren2,3, Melody C Carter4
1Department of Dermatology, McGovern Medical School at The University of Texas at Houston, Houston, Texas.
Pediatric Dermatology
|March 5, 2019
Abstract:
Mastocytosis is an accumulation of clonal mast cells within tissues, commonly caused by mutations in the KIT proto-oncogene. This report describes the management of a neonate with diffuse cutaneous mastocytosis (DCM) caused by a rare activating KIT mutation, specifically internal tandem duplication of the Ala502Tyr503 pair on exon 9, and reviews current data regarding work-up of DCM in pediatric patients.
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