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Multiple primary tumours in oral cancer
International Journal of Oral and Maxillofacial Surgery
|February 1, 1986
Summary
In oral cancer patients, 17.6% developed second primary tumors. Lower oral cavity tumors showed a higher rate of second primaries, particularly in males, suggesting routine panendoscopy may not be valid.
Area of Science:
- Oncology
- Head and Neck Surgery
Background:
- Second primary tumors (SPTs) are a concern in oral cancer management.
- Understanding the incidence and risk factors for SPTs is crucial for patient care.
Purpose of the Study:
- To investigate the incidence of second primary tumors in patients with oral cancer.
- To identify risk factors associated with the development of SPTs.
- To evaluate the utility of panendoscopy in detecting SPTs.
Main Methods:
- Retrospective analysis of 210 oral cancer cases.
- Recording of patient demographics, tumor location, and occurrence of SPTs.
- Statistical analysis to determine significant differences in SPT rates.
Main Results:
- A total of 38 (17.6%) second primary tumors were identified.
- Males had a higher incidence of SPTs (21.4%) than females (12%), though not statistically significant.
- Index tumors in the lower oral cavity (e.g., floor of mouth) had a significantly higher rate of SPTs (26.6%) compared to other oral sites (11.5%), especially in males (p<0.05).
- Only 4 synchronous tumors were found, and panendoscopy would not have improved early diagnosis in these cases.
Conclusions:
- The incidence of second primary tumors in oral cancer is significant.
- Tumor location, particularly in the lower oral cavity, is a key risk factor for SPTs.
- Routine panendoscopy for all oral cancer patients may not be a cost-effective or necessary diagnostic tool.