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Updated: Jan 28, 2026

Orthotopic Mouse Model of Colorectal Cancer
Published on: December 4, 2007
[Role of adipose tissue in the development and progression of colorectal cancer]
R A Moskalenko1, Yu S Korneva2
1Medical Institute, Sumy State University, Ministry of Education and Science of Ukraine, Sumy, Ukraine.
Abstract:
The paper gives the current data available in the literature on the relationship and pathogenetic mechanisms of influence of adipose tissue on colorectal carcinogenesis. It considers the aspects of changes in adipose tissue and microenvironment of the tumor itself, including those under the influence of biologically active substances secreted by adipocytes; differences in subcutaneous and visceral fat and their importance in the development and progression of colorectal cancer (CRC), as well as the role of adipose tissue-derived stem cells. Understanding these mechanisms for adipose tissue influence on CRC will assist not only in preventing this disease, but also in searching for new therapeutic targets.
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