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[Morphofunctional features of non-functioning pituitary adenomas].

A K Eremkina1, L K Dzeranova1, E K Pigarova1

  • 1National Medical Research Center for Endocrinology, Ministry of Health of Russia, Moscow, Russia.

Arkhiv Patologii
|March 5, 2019
PubMed
Summary
This summary is machine-generated.

Non-functioning pituitary adenomas (NFPAs) are a diverse group of tumors. A new classification using transcription factors aids in identifying less differentiated types and understanding their behavior.

Keywords:
aggressivenesshigh-risk pituitary adenomasimmunohistochemical analysisnon-functioning pituitary adenomassilent pituitary adenomastranscription factors

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Area of Science:

  • Endocrinology
  • Oncology
  • Pathology

Background:

  • Non-functioning pituitary adenomas (NFPAs) constitute approximately 30% of pituitary tumors.
  • NFPAs lack significant secretory activity, complicating clinical diagnosis and classification.
  • Previous classification relied on pituitary tropic hormone immunoreactivity, overlooking tumor heterogeneity.

Purpose of the Study:

  • To present the revised WHO classification of pituitary adenomas (4th edition, 2017).
  • To highlight the role of transcription factor antibodies in classifying NFPAs.
  • To discuss theories on silent adenomas and identify proliferative/prognostic markers.

Main Methods:

  • Review of the 2017 WHO Classification of Tumors of Endocrine Organs.
  • Application of transcription factor antibodies for histopathological subtyping.
  • Analysis of theories regarding silent adenomas and prognostic markers.

Main Results:

  • The 2017 WHO classification emphasizes adenohypophysial-cell lineage for subtype designation.
  • Transcription factor antibodies enable recognition of less differentiated and novel tumor types.
  • New insights into silent adenomas and prognostic markers are provided.

Conclusions:

  • The revised classification, incorporating transcription factors, offers a more precise approach to NFPAs.
  • This advancement is crucial for understanding the heterogeneity and behavior of pituitary adenomas.
  • Further research into proliferative and prognostic markers will refine clinical management.