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Updated: Jan 28, 2026
09:21
Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
12.5K
[Thrombolytic therapy of ischemic stroke]
E I Gusev1, M Yu Martynov1, A N Yasamanova1
1Pirogov Russian National Research Medical University, Moscow, Russia.
Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|March 5, 2019
Summary
Reperfusion therapy, including thrombolysis, is crucial for treating ischemic stroke and other vascular events. Research continues to develop effective and safe thrombolytic agents for improved patient outcomes.
Area of Science:
- Cardiovascular Medicine
- Neurology
- Pharmacology
Background:
- Ischemic stroke treatment relies heavily on reperfusion strategies.
- Thrombolytic medications have evolved significantly since the 1950s.
- Recombinant tissue plasminogen activator (rt-PA) is a cornerstone of modern reperfusion therapy.
Purpose of the Study:
- To review the historical development and current status of thrombolytic agents in reperfusion therapy.
- To highlight advancements in tissue plasminogen activator (t-PA) variants.
- To discuss the challenges and potential of external plasminogen activators.
Main Methods:
- Historical review of thrombolysis research and clinical application.
- Analysis of the evolution of thrombolytic drug development.
- Discussion of pharmacological properties and clinical use of various thrombolytic agents.
Main Results:
- Thrombolysis has transitioned from early agents like streptokinase to advanced rt-PA.
- Modified t-PA variants offer improved pharmacokinetic and pharmacodynamic profiles.
- External plasminogen activators (e.g., streptokinase, desmoteplase) present unique therapeutic opportunities and challenges.
Conclusions:
- Thrombolysis remains a vital reperfusion strategy for acute vascular thrombotic events.
- Ongoing research focuses on enhancing fibrinolytic activity and specificity while mitigating immunogenicity.
- Development of novel thrombolytic agents aims to improve efficacy and safety in clinical practice.
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