[Prognostic markers of ischemic stroke outcome]

Area of Science:

• Neurology
• Hematology
• Clinical Medicine

Background:

• Ischemic stroke (IS) is a leading cause of death and disability worldwide.
• Predicting IS outcomes is crucial for timely and effective patient management.
• Peripheral blood leukocyte indices are potential biomarkers for disease severity and prognosis.

Purpose of the Study:

• To evaluate the clinical significance of peripheral blood leukocyte indices in predicting ischemic stroke outcomes.
• To assess the correlation between leukocyte indices and the severity of neurological deficit in IS patients.

Main Methods:

• Retrospective analysis of 45 ischemic stroke patient case histories.
• Calculation of the index of blood leukocyte shift (IBLS) and the index of blood leukocytes to ESR ratio (BLESR) from peripheral blood analysis.
• Assessment of neurological deficit severity using the NIHSS scale.

Main Results:

• Patients with unfavorable IS outcomes exhibited significantly higher IBLS (7.73±2.72) and BLESR (3.39±1.54) compared to those with favorable outcomes (IBLS: 3.85±0.67, BLESR: 2.47±1.22).
• A moderate positive correlation (0.55) was observed between higher IBLS values and neurological deficit severity in patients with unfavorable outcomes.
• Higher values of IBLS and BLESR were associated with an increased probability of death from ischemic stroke.

Conclusions:

• Peripheral blood leukocyte indices (IBLS and BLESR) are valuable predictors of ischemic stroke prognosis.
• Elevated IBLS and BLESR levels indicate a higher risk of mortality and severe neurological deficits.
• These indices can aid clinicians in determining appropriate treatment strategies during the acute phase of ischemic stroke.