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Granular cell ameloblastic fibroma, ultrastructure and histogenesis
International Journal of Oral and Maxillofacial Surgery
|April 1, 1986
Summary
This study reports a rare peripheral granular cell ameloblastic fibroma in a Japanese woman. Ultrastructural analysis suggests granular cells originate from mesenchymal cells, possibly fibroblasts, influenced by ectomesenchymal factors.
Area of Science:
- Oral pathology
- Odontogenic tumors
- Granular cell lesions
Background:
- Ameloblastic fibroma is a rare odontogenic tumor.
- Peripheral variants are less common than central ones.
- Granular cell changes in ameloblastic fibroma are infrequent.
Observation:
- A case of peripheral granular cell ameloblastic fibroma occurred in the right upper premolar gingiva of a 34-year-old Japanese woman.
- Ultrastructural examination showed distinct granular cells and epithelial components.
- Direct continuity was observed between the overlying gingival epithelium and the tumor's epithelial component.
Findings:
- Ultrastructural findings indicated granular cells likely originated from mesenchymal cells, specifically fibroblasts.
- The study suggests a potential role for residual ectomesenchymal influence.
- This influence may drive the proliferation and subsequent transformation of both epithelial and mesenchymal components into granular cells.
Implications:
- This case contributes to understanding the histogenesis of granular cell ameloblastic fibroma.
- It highlights the potential origin of granular cells from mesenchymal elements.
- The findings may refine diagnostic criteria and therapeutic approaches for this rare tumor.