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Updated: Jan 28, 2026

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
Published on: November 26, 2018
Abnormalities in chemokine receptor recycling in chronic lymphocytic leukemia
Laura Patrussi1, Nagaja Capitani2, Cosima T Baldari2
1Department of Life Sciences, University of Siena, Via Aldo Moro 2, 53100, Siena, Italy. patrussi2@unisi.it.
Abstract:
In addition to their modulation through de novo expression and degradation, surface levels of chemokine receptors are tuned by their ligand-dependent recycling to the plasma membrane, which ensures that engaged receptors become rapidly available for further rounds of signaling. Dysregulation of this process contributes to the pathogenesis of chronic lymphocytic leukemia (CLL) by enhancing surface expression of chemokine receptors, thereby favoring leukemic cell accumulation in the protective niche of lymphoid organs. In this review, we summarize our current understanding of the process of chemokine receptor recycling, focusing on the impact of its dysregulation in CLL.
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