Related Experiment Video
Updated: Jan 28, 2026
08:06
Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice
Published on: November 27, 2019
9.5K
Correction to: Urinary metabolic profiling of asymptomatic acute intermittent porphyria using a rule-mining-based
Margaux Luck1,2,3,4, Caroline Schmitt5,6,7, Neila Talbi5,6,7
1INSERM U1147, Centre Universitaire des Saints Pères, Paris, France.
Summary
This study used a rule-mining algorithm for urinary metabolic profiling in asymptomatic acute intermittent porphyria (AIP). The findings help in understanding AIP metabolic patterns in individuals without symptoms.
Area of Science:
- Biochemistry
- Metabolomics
- Genetics
Background:
- Acute intermittent porphyria (AIP) is a rare genetic disorder.
- Asymptomatic AIP patients may have subtle metabolic alterations.
- Current diagnostic methods may not detect early metabolic changes.
Purpose of the Study:
- To investigate urinary metabolic profiles in asymptomatic AIP patients.
- To identify potential biomarkers for early detection of AIP.
- To apply a novel rule-mining algorithm for metabolic data analysis.
Main Methods:
- Urine samples were collected from asymptomatic AIP patients and healthy controls.
- Metabolomic analysis was performed using advanced analytical techniques.
- A rule-mining-based algorithm was employed to identify significant metabolic patterns.
Main Results:
- Distinct urinary metabolic profiles were observed in asymptomatic AIP patients.
- Specific metabolites and metabolic pathways were identified as potential indicators of AIP.
- The rule-mining algorithm successfully differentiated between AIP patients and controls.
Conclusions:
- Urinary metabolic profiling can reveal early signs of AIP in asymptomatic individuals.
- Rule-mining algorithms offer a powerful tool for analyzing complex metabolomic data.
- These findings may contribute to improved early diagnosis and management of AIP.
Related Concept Videos
02:55Exceptions to the Octet Rule
37.4K
Many covalent molecules have central atoms that do not have eight electrons in their Lewis structures. These molecules fall into three categories:
37.4K
02:36Lewis Symbols and the Octet Rule
80.5K
Chemical bonds are complex interactions between two or more atoms or ions, which reduce the potential energy of the molecule. Gilbert N. Lewis developed a model called the Lewis model that simplified the depiction of chemical bond formation and provided straightforward explanations for the chemical bonds seen in most common compounds.
80.5K
03:02The Aufbau Principle and Hund's Rule
72.6K
To determine the electron configuration for any particular atom, we can build the structures in the order of atomic numbers. Beginning with hydrogen, and continuing across the periods of the periodic table, we add one proton at a time to the nucleus and one electron to the proper subshell until we have described the electron configurations of all the elements. This procedure is called the aufbau principle, from the German word aufbau (“to build up”). Each added electron occupies the...
72.6K
01:15Distance Corrections
282
To achieve precise distance measurements, especially in surveying and construction, certain corrections must be applied to account for potential sources of error like the standardization errors, temperature variations, and slope adjustments.Standardization error emerges when measurement equipment undergoes changes, such as wear, repairs, or weather impacts. To address this, surveyors compare the equipment’s readings to a standard. This process identifies any deviation that might lead to...
282
01:30The Quotient Rule
50
The quotient rule is a fundamental differentiation technique in calculus used to differentiate functions expressed as a ratio of two differentiable functions. Given a function of the form:Where g(x) and h(x) are both differentiable and h(x) ≠ 0, the derivative of f(x) is given by:Example:The quotient rule is beneficial when differentiating rational functions, trigonometric ratios, and exponential functions. For example, given:applying the quotient rule,This rule is essential in solving...
50
01:20Midpoint Rule
56
Approximating areas under curved boundaries is a common problem in applied mathematics, particularly when an exact calculation is difficult or impractical. One effective numerical method for this purpose is the Midpoint Rule, which provides an estimate of the area under a curve by using rectangular approximations over a specified interval.Description of the Midpoint RuleThe Midpoint Rule begins by dividing the given interval into a number of equal subintervals. For each subinterval, the...
56