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Rucaparib: A Review in Ovarian Cancer

Matt Shirley1

  • 1Springer, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand. demail@springer.com.

Targeted Oncology
|March 5, 2019
PubMed

Insights

Rucaparib, a PARP inhibitor, shows significant efficacy in treating advanced ovarian cancer. It is effective as both a treatment and maintenance therapy for patients with BRCA mutations and platinum-sensitive disease.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Rucaparib is a poly(ADP-ribose) polymerase (PARP) inhibitor approved for BRCA-mutated ovarian cancer.
  • It is used for treatment after chemotherapy and as maintenance therapy for recurrent or relapsed ovarian cancer.

Purpose of the Study:

  • To evaluate the clinical activity and tolerability of rucaparib in advanced ovarian cancer.
  • To assess rucaparib's efficacy as third-line treatment and maintenance therapy.

Main Methods:

  • Analysis of patients from two Phase II clinical trials for third-line treatment.
  • Evaluation of the randomized, placebo-controlled, Phase III ARIEL3 trial for maintenance therapy.

Main Results:

  • Rucaparib demonstrated a 54% objective response rate in third-line treatment of BRCA-mutated ovarian cancer.
  • The ARIEL3 trial showed significantly improved progression-free survival with rucaparib maintenance therapy in platinum-sensitive ovarian cancer.
  • Rucaparib exhibited an acceptable and manageable tolerability profile.

Conclusions:

  • Rucaparib is a valuable treatment option for advanced ovarian cancer.
  • It offers clinical benefits in both treatment and maintenance settings for specific patient populations.

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