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An ultrastructural study of binucleate plasma cells.

Y Jinn-Fei, N G el-Labban

    Journal of Oral Pathology
    |February 1, 1986
    PubMed
    Summary

    Binucleate plasma cells, identified in 33 of 50 surgical specimens across 10 diseases, likely form through cell fusion. These cells, with two distinct nuclei, were observed in various pathological conditions.

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    Area of Science:

    • Pathology
    • Cell Biology
    • Immunology

    Background:

    • Plasma cells are crucial for antibody production.
    • Binucleate cells are uncommon in many cell types.
    • Understanding plasma cell morphology can provide insights into cellular processes.

    Purpose of the Study:

    • To investigate the presence and morphology of binucleate plasma cells in surgical specimens.
    • To explore the potential formation mechanisms of binucleate plasma cells.
    • To determine if binucleate plasma cells are associated with specific diseases.

    Main Methods:

    • Examination of 50 surgical specimens from 10 different diseases.
    • Morphological and ultrastructural analysis of plasma cells.
    • Serial examination to observe nuclear arrangement and cell apposition.

    Main Results:

    • Binucleate plasma cells were found in 33 specimens (66%).
    • These cells possessed two nuclei with characteristic plasma cell heterochromatin.
    • Evidence of cell fusion, including cytoplasmic bridges and indistinct membranes, was observed between plasma cells.

    Conclusions:

    • Binucleate plasma cells likely arise from the fusion of mononuclear plasma cells.
    • The presence of binucleate plasma cells is not restricted to a single disease entity.
    • Cell fusion may be a mechanism contributing to the diversity of plasma cell populations in disease states.

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