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Potential Anticancer Agents Characterized from Selected Tropical Plants.

Yulin Ren¹, Esperanza J Carcache de Blanco¹, James R Fuchs¹

¹Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy , The Ohio State University , Columbus , Ohio 43210 , United States.

Journal of Natural Products

|March 5, 2019

Summary

This summary is machine-generated.

Higher plants offer promising anticancer compounds. This review details discoveries of biflavonoids, lignans, and other compounds from tropical flora, highlighting their potential in cancer chemotherapy.

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Area of Science:

Phytochemistry
Pharmacology
Natural Products Chemistry

Background:

Higher plants are a rich source of clinically useful anticancer agents.
Plant-derived compounds offer diverse mechanisms of action against cancer cells.
There is ongoing interest in discovering novel plant secondary metabolites for cancer chemotherapeutics.

Purpose of the Study:

To review progress in discovering plant-derived anticancer compounds.
To present characterized anticancer leads from tropical plants.
To discuss structure-activity relationships and mechanisms of action.

Main Methods:

Characterization of plant-derived compounds from tropical flora.
Investigation of preliminary structure-activity relationships.
In vivo testing and analysis of cellular mechanisms of action.
Inclusion of relevant published work on similar compound classes.

Main Results:

Several potential anticancer leads from biflavonoid, lignan, sesquiterpene, steroid, and xanthone classes were identified.
Compounds were isolated from tropical plants across three countries.
Preliminary structure-activity relationships and mechanistic studies were conducted.

Conclusions:

Tropical plants are a valuable resource for novel anticancer drug discovery.
Further research into these plant-derived compounds could lead to new cancer chemotherapeutics.
The identified compounds show promise for development as anticancer agents.