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Related Experiment Videos

Long-term total intraperitoneal nutrition in a rabbit model.

M M Stone, S J Mulvihill, K J Lewin

    Journal of Pediatric Surgery
    |March 1, 1986
    PubMed
    Summary

    Total intraperitoneal nutrition is a viable long-term feeding method, even after significant small bowel resection. This method showed comparable survival and weight gain to intravenous nutrition, with less liver toxicity.

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    Area of Science:

    • Surgical Nutrition
    • Gastroenterology
    • Animal Models

    Background:

    • Parenteral nutrition is crucial for patients unable to absorb nutrients enterally.
    • Intravenous (IV) administration of total parenteral nutrition (TPN) can lead to complications like liver dysfunction.
    • Intraperitoneal (IP) nutrition offers a potential alternative route for nutrient delivery.

    Purpose of the Study:

    • To evaluate the efficacy and safety of total intraperitoneal (IP) nutrition as a sole nutritional source in a rabbit model.
    • To assess the impact of 50% small bowel resection (SBR) on IP nutrition absorption.
    • To compare the incidence of liver toxicity between IP and IV-TPN.

    Main Methods:

    • 28 rabbits received a nutrient mixture (dextrose, amino acids, lipids) for 21 days.

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  • Twenty rabbits received IP nutrition via catheters; 8 of these had undergone 50% SBR.
  • Eight control rabbits received the same solution via intravenous total parenteral nutrition (IV-TPN).

    • Main Results:

    • Survival rates were 75% in both IP and IV-TPN groups.
    • Weight gain was comparable between IP-infused and IV-TPN rabbits.
    • IP nutrition resulted in less severe biochemical and histologic liver toxicity compared to IV-TPN.
    • 50% SBR did not significantly affect body weight or blood chemistry in rabbits receiving IP nutrition.
    • Mild chemical peritonitis was observed with IP nutrition but resolved after discontinuation.

    Conclusions:

    • Total calorie support can be safely delivered via the peritoneal cavity on a long-term basis.
    • 50% small bowel resection minimally impacts the absorption of nutrients via IP administration.
    • IP nutrition may be associated with less severe liver dysfunction compared to IV-TPN.