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Polysulfone corneal lenses.

S L Lane, R L Lindstrom, J D Cameron

    Journal of Cataract and Refractive Surgery
    |January 1, 1986
    PubMed
    Summary
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    Polysulfone intraocular lenses show potential for correcting refractive errors. However, complications arose in animal models, necessitating further research into polysulfone

    Area of Science:

    • Ophthalmology
    • Biomaterials Science
    • Materials Engineering

    Background:

    • Polysulfone, a thermoplastic, possesses a high refractive index (1.633) enabling thin optical lens manufacturing.
    • Previous clinical use of polysulfone intraocular lenses by D. Peter Choyce suggests efficacy in correcting significant refractive errors.

    Purpose of the Study:

    • To evaluate the safety and efficacy of polysulfone as an intracorneal lens material.
    • To assess polysulfone's performance in laboratory animal models for refractive error correction.

    Main Methods:

    • Surgical implantation of 5.0-mm to 6.0-mm diameter hyperopic and myopic polysulfone lenses into the corneal stroma of monkeys, baboons, and cats.
    • Sham lamellar dissection performed in the contralateral eye as a control.
    • Ophthalmoscopic examination for media clarity at three to six-month follow-ups.

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    Main Results:

    • Clear media maintained in 100% of monkey eyes, 12.5% of baboon eyes, and 70.0% of cat eyes.
    • Complications observed included interface opacities, lens extrusion, anterior corneal necrosis, refractile particles, and epithelial thinning.

    Conclusions:

    • Polysulfone demonstrates potential as an intracorneal lens material but presents significant safety concerns in animal models.
    • Further investigation is required to address complications and determine the long-term viability of polysulfone for corneal implantation.