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Updated: Jan 28, 2026

In vivo Imaging and Therapeutic Treatments in an Orthotopic Mouse Model of Ovarian Cancer
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In vivo Imaging and Therapeutic Treatments in an Orthotopic Mouse Model of Ovarian Cancer

Published on: August 17, 2010

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New insight into NANOG: A novel therapeutic target for ovarian cancer (OC)

Iyer Mahalaxmi1, Subramaniam Mohana Devi2, Jayaramayya Kaavya1

  • 1Department of Zoology, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore 641043, India.

European Journal of Pharmacology
|March 5, 2019
PubMed

Insights

Nanog, a key factor in cancer stem cells (CSCs), drives ovarian cancer (OC) chemoresistance and recurrence. Targeting Nanog offers a promising strategy to improve chemotherapy outcomes for OC patients.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Stem Cell Research

Background:

  • Ovarian cancer (OC) presents critical challenges including metastasis, drug resistance, and recurrence.
  • Cancer stem cells (CSCs) are implicated in OC's aggressive nature, contributing to treatment failure.
  • Nanog, a pluripotency transcription factor, regulates CSCs and is increasingly recognized for its role in chemoresistance.

Purpose of the Study:

  • To review the multifaceted functions of Nanog in normal and ovarian cancer cells.
  • To elucidate Nanog's specific involvement in ovarian cancer tumorigenesis and the development of chemoresistance.
  • To highlight therapeutic strategies targeting Nanog for ovarian cancer treatment.

Main Methods:

  • Literature review focusing on Nanog's role in cancer stem cells.
  • Analysis of studies investigating Nanog's function in ovarian cancer development and progression.
  • Examination of research on Nanog-targeting therapeutic approaches.

Main Results:

  • Nanog expression is linked to cancer stem cell properties, including self-renewal and tumor initiation.
  • Nanog significantly contributes to multi-drug resistance and recurrence in ovarian cancer.
  • Targeting Nanog presents a potential therapeutic avenue to overcome chemoresistance in OC.

Conclusions:

  • Nanog plays a crucial role in ovarian cancer stem cell maintenance and chemoresistance.
  • Developing strategies to inhibit Nanog could enhance the efficacy of chemotherapy for ovarian cancer.
  • Further research into Nanog inhibition is warranted to improve patient outcomes in ovarian cancer treatment.
Keywords:
Cancer Stem Cells (CSCs)ChemotherapyNanogOvarian cancer (OC)

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