Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

465
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
465
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

548
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
548
Autophagy01:27

Autophagy

5.8K
Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
5.8K
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

512
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
512
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

390
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
390
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

580
Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
580

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mavacamten shows broad benefit in human and mouse models of MYBPC3-related hypertrophic cardiomyopathy.

Nature cardiovascular research·2026
Same author

JAK1/2 inhibitor ruxolitinib reduces aggregates in cardiac proteinopathy.

EMBO molecular medicine·2026
Same author

Simtuzumab Attenuates Loxl2-Mediated Extracellular Matrix Remodeling and Preserves Cardiac Function in <i>LMNA</i> Mutation-Induced Dilated Cardiomyopathy.

Circulation. Heart failure·2026
Same author

Generation of human induced pluripotent stem cell lines carrying a heterozygous and homozygous PRKD1 c.1774G > A genetic variant causing syndromic congenital defects.

Stem cell research·2026
Same author

Translational Insights Into Myocardial Deformation and Fibrosis in Hypertrophic Cardiomyopathy Using Diffusion Tensor MRI.

JACC. Advances·2025
Same author

Mechanisms and Therapies of Hypertrophic Cardiomyopathy.

Annual review of physiology·2025

Related Experiment Video

Updated: Jan 28, 2026

Activating Autophagy by Aerobic Exercise in Mice
08:44

Activating Autophagy by Aerobic Exercise in Mice

Published on: February 3, 2017

12.7K

Autophagy in cardiomyopathies.

Antonia T L Zech1, Sonia R Singh2, Saskia Schlossarek1

  • 1Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg, Hamburg, Germany; German Centre for Cardiovascular Research, Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany.

Biochimica Et Biophysica Acta. Molecular Cell Research
|March 5, 2019
PubMed
Summary

Autophagy, a cellular self-eating process, is crucial for maintaining heart health. This review explores its role in cardiac function, disease, and potential therapies.

Keywords:
AutophagosomeAutophagyCardiomyopathyHeartLysosome

More Related Videos

Live Cell Imaging of Early Autophagy Events: Omegasomes and Beyond
09:00

Live Cell Imaging of Early Autophagy Events: Omegasomes and Beyond

Published on: July 27, 2013

19.2K
Use of Shigella flexneri to Study Autophagy-Cytoskeleton Interactions
12:52

Use of Shigella flexneri to Study Autophagy-Cytoskeleton Interactions

Published on: September 9, 2014

16.4K

Related Experiment Videos

Last Updated: Jan 28, 2026

Activating Autophagy by Aerobic Exercise in Mice
08:44

Activating Autophagy by Aerobic Exercise in Mice

Published on: February 3, 2017

12.7K
Live Cell Imaging of Early Autophagy Events: Omegasomes and Beyond
09:00

Live Cell Imaging of Early Autophagy Events: Omegasomes and Beyond

Published on: July 27, 2013

19.2K
Use of Shigella flexneri to Study Autophagy-Cytoskeleton Interactions
12:52

Use of Shigella flexneri to Study Autophagy-Cytoskeleton Interactions

Published on: September 9, 2014

16.4K

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Physiology

Background:

  • Autophagy is a fundamental eukaryotic process for degrading cellular components via lysosomes.
  • It maintains cellular homeostasis by removing damaged structures and supplying energy.
  • Growing evidence highlights autophagy's significant role in cardiac homeostasis and function.

Purpose of the Study:

  • To review the diverse forms of mammalian autophagy.
  • To detail the regulation and monitoring of autophagy, with a focus on the heart.
  • To examine autophagy's involvement in cardiomyopathies and therapeutic strategies.

Main Methods:

  • Literature review of mammalian autophagy.
  • Analysis of autophagy regulation and monitoring techniques.
  • Examination of studies on autophagy in cardiac conditions.

Main Results:

  • Describes various mammalian autophagy pathways.
  • Details methods for studying autophagy in cardiac tissue.
  • Connects autophagy dysfunction to cardiomyopathy development.

Conclusions:

  • Autophagy is vital for cardiac health and function.
  • Dysregulation of autophagy contributes to cardiomyopathies.
  • Targeting autophagy presents potential therapeutic avenues for heart disease.