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Zinc deficiency and lymphocyte subpopulations. A study by flow cytometry
JPEN. Journal of Parenteral and Enteral Nutrition
|March 1, 1986
Summary
Zinc deficiency can impair immunity, as seen in a Crohn's patient with acrodermatitis enteropathica. Monitoring lymphocyte surface markers like OKT-9 and OKM-5 may help manage zinc levels during total parenteral nutrition.
Area of Science:
- Immunology
- Gastroenterology
- Nutritional Science
Background:
- Crohn's disease is an inflammatory bowel condition impacting nutrient absorption.
- Total parenteral nutrition (TPN) can lead to deficiencies, including zinc.
- Zinc deficiency is known to compromise immune function.
Observation:
- A case study of an 18-year-old female with relapsing Crohn's disease and acrodermatitis enteropathica due to zinc deficiency during TPN.
- Flow cytometry revealed decreased T-helper lymphocytes and elevated OKM-5+ lymphocytes before zinc treatment.
- Cytoplasmic modifications and increased OKT-9 (a marker for high metabolism) were noted.
Findings:
- Zinc supplementation rapidly increased T-helper lymphocytes.
- A proportional decrease in OKM-5+ lymphocytes was observed post-zinc supplementation.
- Lymphocyte surface marker profiles shifted towards normal with zinc repletion.
Implications:
- Lymphocyte surface markers (OKM-5, OKT-9) may serve as indicators for monitoring zinc status.
- This approach could be valuable for patients on TPN at risk of zinc deficiency.
- Understanding these immune changes aids in managing complex gastrointestinal and nutritional disorders.