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Updated: Jan 28, 2026

Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice
Published on: October 13, 2023
γδ T lymphocytes in the pathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis
Michał K Zarobkiewicz1, Wioleta Kowalska1, Jacek Roliński1
1Chair and Department of Clinical Immunology, Medical University of Lublin, Poland.
Abstract:
The aim of the current review is to summarize the results of studies on the role of γδ T cells in the pathogenesis of multiple sclerosis and its animal model - the experimental autoimmune encephalomyelitis. Despite the fact that numerous studies have been performed, the role of γδ T is still not fully understood. It seems that there are two distinct subpopulations - one exacerbating the disease (IL-17-producing) and the other playing a protective role (IFN-γ-secreting). Nevertheless, future studies are required for an understanding of γδ T cells role in multiple sclerosis.
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