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Association between Trimetazidine and Parkinsonism: A Population-Based Study.
Jeongyoon Kwon1, Yun Mi Yu2,3, Seungyeon Kim1
1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea.
Neuroepidemiology
|March 5, 2019
Summary
Trimetazidine (TMZ) use is a significant predictor of drug-induced parkinsonism (DIP) in angina patients. Close monitoring for DIP is recommended for all patients prescribed TMZ, especially older adults and those with a history of stroke.
Area of Science:
- Pharmacology
- Neurology
- Public Health
Background:
- Drug-induced parkinsonism (DIP) is a known adverse effect of trimetazidine (TMZ), an antianginal drug.
- Limited research exists on the association between DIP and TMZ, particularly using population-based data.
Purpose of the Study:
- To investigate the link between TMZ use and DIP in angina patients.
- To identify risk factors for DIP among TMZ users.
Main Methods:
- A cross-sectional study utilized the Korean National Healthcare claims database (2014).
- Patients aged 40+ with angina were analyzed.
- Multivariate logistic regression adjusted for confounders including age, sex, insurance, comorbidities, and concurrent medications.
Main Results:
- TMZ was prescribed to 19% of patients; 2.5% of TMZ users had prior movement disorders.
- TMZ use significantly predicted new parkinsonism diagnoses (aOR 1.39).
- Advanced age (≥65 years) and stroke comorbidity were also significant predictors.
Conclusions:
- TMZ treatment is a statistically significant predictor of new-onset parkinsonism.
- Close monitoring and patient education regarding DIP are crucial for all TMZ prescriptions.
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