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Related Experiment Videos

Venous catheter-associated candidemia.

H D Rose

    The American Journal of the Medical Sciences
    |May 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Catheter-associated candidemia can often be resolved by removing the venous catheter, avoiding systemic antifungal agents. Prompt management prevents serious metastatic complications like endophthalmitis or endocarditis.

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    Area of Science:

    • Infectious Diseases
    • Medical Mycology
    • Critical Care Medicine

    Background:

    • Venous catheter-associated candidemia is a serious bloodstream infection.
    • Candida species are a significant cause of hospital-acquired infections.
    • Indwelling vascular catheters are a major risk factor for candidemia.

    Purpose of the Study:

    • To evaluate outcomes of catheter-associated candidemia.
    • To determine the impact of catheter removal on recovery.
    • To identify risk factors for metastatic complications.

    Main Methods:

    • Retrospective analysis of 55 patients with venous catheter-associated candidemia over 13 years.
    • Assessment of clinical outcomes, including fever resolution, metastatic infections, and mortality.

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  • Correlation of outcomes with management strategies, particularly catheter removal and antifungal therapy.

    • Main Results:

    • Thirty-five of 55 patients recovered; 26 became afebrile within 72 hours of catheter removal without systemic antifungal agents.
    • Four patients developed endophthalmitis, with three experiencing significant vision loss.
    • Nine patients with persistent candidemia post-catheter removal required antifungal therapy but did not develop metastatic infections.
    • Twenty critically ill patients died during fungemia, including two with Candida endocarditis.

    Conclusions:

    • Venous catheter removal is crucial for resolving candidemia and preventing metastatic complications.
    • Systemic antifungal therapy may be necessary for persistent infections but is not always required for initial recovery.
    • Preventing candidemia through proper catheter care is paramount.
    • Timely management of candidemia episodes can avert severe outcomes such as endophthalmitis and endocarditis.