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The polyol pathway, sorbinil, and renal dysfunction.

A Beyer-Mears

    Metabolism: Clinical and Experimental
    |April 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Sorbinil treatment reduced urinary protein excretion in diabetic rats, suggesting aldose reductase inhibition may protect against diabetic nephropathy. This enzyme inhibition prevented abnormal protein appearance, indicating a potential therapeutic strategy.

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    Area of Science:

    • Nephrology
    • Endocrinology
    • Biochemistry

    Background:

    • Diabetic nephropathy, a complication of Type I diabetes, has a poor prognosis after proteinuria onset.
    • Aldose reductase is implicated in the pathogenesis of diabetic proteinuria.

    Purpose of the Study:

    • To investigate if sorbinil, an aldose reductase inhibitor, can diminish or reverse urinary protein excretion in diabetic rats.
    • To assess the effect of sorbinil on specific urinary protein profiles in a diabetic model.

    Main Methods:

    • Onset and reversal studies were conducted using sorbinil (20 mg/kg) in streptozotocin-induced diabetic rats.
    • 24-hour urine samples were analyzed weekly for protein content and molecular weight distribution via polyacrylamide gel electrophoresis.
    • Protein patterns were quantitated using laser densitometric analysis.

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    Main Results:

    • Daily sorbinil administration for ten weeks significantly diminished total protein excretion in diabetic rats.
    • Sorbinil protected against the appearance of abnormal urinary proteins characteristic of untreated diabetes, including albuminuria.
    • The drug prevented the emergence of novel proteins in the 30,000-65,000 and 70,000-120,000 dalton ranges.

    Conclusions:

    • Aldose reductase inhibition with sorbinil effectively reduces proteinuria in diabetic rats.
    • Sorbinil demonstrates potential in preventing or mitigating the development of diabetic nephropathy by altering urinary protein profiles.