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Globalization of pediatric research: pharmacological RCTs in Latin America

Federica Arienti1,2, Claudia Pansieri3, Chiara Pandolfini1

  • 1Laboratory for Mother and Child Health, Department of Public Health, IRCCS - Istituto di RicercheFarmacologiche "Mario Negri", Via Giuseppe la Masa 19, 20156, Milan, Italy.

Italian Journal of Pediatrics
|March 6, 2019
PubMed

Insights

Globalization shifted clinical trials to low-middle income countries, potentially neglecting child health needs. Research in Latin America shows a mismatch between children's health priorities and conducted pharmacological trials.

Area of Science:

  • Pediatric clinical research
  • Global health equity
  • Drug development ethics

Background:

  • Globalization has led to increased clinical trials in low- and middle-income countries (LMICs).
  • This shift raises ethical concerns about prioritizing diseases prevalent in developed nations over those affecting children in LMICs.
  • Ethical considerations in international clinical research are paramount.

Discussion:

  • Analysis of 253 published and 69 ongoing pharmacological randomized controlled trials (RCTs) in Latin America (2000-2015) exclusively involving children.
  • Identified a significant shift in research priorities, with over 50% of previously highly investigated diseases no longer being priorities.
  • Brazil and Mexico emerged as the most active countries in pediatric research.

Key Insights:

  • A substantial gap exists between the actual health needs of children in Latin America and the focus of scientific research.
  • Research priorities have shifted, with some diseases gaining more attention while others are neglected.
  • The geographical distribution of trials highlights Brazil and Mexico as key locations for pediatric drug research.

Outlook:

  • Future research should align with the specific health burdens faced by children in LMICs.
  • Strengthening ethical frameworks for international clinical trials is crucial to ensure equitable research focus.
  • Addressing the identified research gaps is essential for improving child health outcomes globally.

Keywords:
Developing countriesGlobalizationLatin AmericaRandomized clinical trials

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