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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
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Psychodynamic therapies emphasize the exploration of unconscious processes and early childhood experiences as fundamental contributors to psychological difficulties. These therapies, deeply rooted in Freud's psychoanalytic theory, aim to uncover and resolve unconscious conflicts, granting individuals insights that promote emotional and behavioral healing. Contemporary psychodynamic approaches have evolved, integrating a broader range of influences and methodologies while still valuing the...
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Humanistic therapies emphasize personal growth, self-understanding, and the fulfillment of human potential. Rooted in the belief that individuals inherently strive toward self-actualization, these approaches encourage clients to explore their feelings and experiences in a supportive, nonjudgmental environment. Humanistic therapies differ from psychodynamic approaches by focusing on conscious experiences, present circumstances, and the potential for self-improvement rather than past conflicts...
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Expression of Exogenous Cytokine in Patient-derived Xenografts via Injection with a Cytokine-transduced Stromal Cell Line
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Cytokine Therapy.

Ann W Silk1, Kim Margolin2

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Hematology/Oncology Clinics of North America
|March 6, 2019
PubMed
Summary
This summary is machine-generated.

Cytokines are key in cancer, influencing disease progression and treatment efficacy. Understanding cytokine networks improves cancer therapies, enhancing benefits and reducing side effects.

Keywords:
CytokineInterferonInterleukinMelanomaRenal cell carcinoma

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Area of Science:

  • Immunology
  • Oncology
  • Molecular Biology

Background:

  • Cytokines are crucial signaling molecules in immune responses.
  • Pathologic states, including malignancy, can hijack cytokine pathways.
  • Dysregulated cytokine signaling contributes to disease progression and treatment resistance.

Purpose of the Study:

  • To review the current understanding of cytokine roles in cancer.
  • To focus on approved and late-stage investigational cytokine-targeting agents.
  • To explore novel therapeutic strategies involving cytokines.

Main Methods:

  • Literature review of cytokine science in malignancy.
  • Analysis of approved and late-stage cytokine-based therapies.
  • Discussion of emerging cytokine-targeting approaches.

Main Results:

  • Cytokine dysregulation is implicated in various cancers.
  • Several cytokine-targeting agents are approved or in advanced development.
  • Novel engineered cytokines show promise for future cancer treatment.

Conclusions:

  • Targeting cytokine networks is a vital strategy in cancer therapy.
  • A deep understanding of cytokine signaling is essential for optimizing treatments.
  • Future directions include developing innovative engineered cytokine therapies for improved outcomes.