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Related Experiment Videos

Sjögren's syndrome in children.

D J Franklin, R J Smith, D A Person

    Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
    |February 1, 1986
    PubMed
    Summary

    Sjögren

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    Back to the basics.

    The New England journal of medicine·2000

    Area of Science:

    • Rheumatology
    • Pediatric Autoimmunology
    • Ophthalmology

    Background:

    • Sjögren's syndrome (SS) is a chronic autoimmune disorder primarily affecting lacrimal and salivary glands, leading to dry eyes and mouth.
    • While typically seen in middle-aged women, SS is underreported in children, necessitating awareness of pediatric symptoms.
    • Diagnosis in children requires consideration of eye irritation, chronic dryness, or salivary gland swelling.

    Observation:

    • A case series details the treatment of five pediatric patients with Sjögren's syndrome at Texas Children's Hospital.
    • One child presented with primary SS, while four had secondary SS associated with juvenile rheumatoid arthritis or systemic lupus erythematosus.
    • Associated autoimmune conditions included polyarteritis nodosa, scleroderma, polymyositis, and chronic lymphocytic thyroiditis.

    Findings:

    • The study highlights that both primary and secondary Sjögren's syndrome may be more common in pediatric populations than previously reported.
    • One patient with secondary SS and thyroiditis developed papillary thyroid carcinoma, indicating a potential link between SS and malignancy.
    • Early recognition and management are crucial to prevent immediate complications like corneal damage and dental decay.

    Implications:

    • Increased awareness of pediatric Sjögren's syndrome is vital for timely diagnosis and intervention.
    • Comprehensive follow-up care can help mitigate long-term morbidity, including the risk of associated malignancies.
    • Symptomatic treatments and prophylactic measures are available to manage SS symptoms and prevent severe outcomes.

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