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Updated: Jan 28, 2026

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

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Published on: May 10, 2022

Nitric Oxide, Iron and Neurodegeneration.

Chao Liu^1,2,3,4, Mui Cheng Liang^1,4, Tuck Wah Soong^1,4,5

¹Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Frontiers in Neuroscience

|March 6, 2019

Summary

Dysregulated iron homeostasis and nitric oxide (NO) contribute to neurodegeneration in Alzheimer's and Parkinson's diseases. Iron chelation therapy shows promise for treating these conditions.

Keywords:

Parkinson’s disease S-nitrosylated proteins iron homeostasis nitric oxide oxidative stress

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Area of Science:

Neuroscience
Biochemistry
Pathology

Background:

Iron is vital for brain function, but excess iron causes oxidative stress and cell death.
Elevated iron levels are observed in Parkinson's and Alzheimer's disease brains.
High concentrations of nitric oxide (NO) are linked to neurodegeneration.

Purpose of the Study:

To review recent advances on the role of dysregulated iron homeostasis in neurodegeneration, focusing on Alzheimer's and Parkinson's diseases.
To discuss iron chelation as a potential therapeutic strategy.
To highlight the impact of NO on iron homeostasis and neurodegeneration.

Main Methods:

Literature review of recent scientific advances.
Analysis of the interplay between iron, nitric oxide, and neurodegenerative processes.
Discussion of therapeutic implications of iron chelation.

Main Results:

Dysregulated iron homeostasis, particularly excess labile iron, contributes to oxidative stress and neurodegeneration.
Increased iron is found in affected brain regions in Alzheimer's and Parkinson's diseases.
Nitric oxide (NO) influences iron homeostasis through gene expression and direct protein modification, potentially exacerbating neurodegeneration.

Conclusions:

Imbalances in iron homeostasis are implicated in neurodegenerative diseases like Alzheimer's and Parkinson's.
Nitric oxide (NO) significantly interacts with iron metabolism, influencing disease progression.
Iron chelation presents a promising therapeutic avenue for neurodegenerative conditions associated with iron dysregulation.