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Source And Potency Of Stem Cells01:27

Source And Potency Of Stem Cells

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Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
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Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Related Experiment Video

Updated: Jan 28, 2026

Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells
22:06

Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells

Published on: February 25, 2007

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Stem Cells from the Apical Papilla: A Promising Source for Stem Cell-Based Therapy.

Jun Kang1,2, Wenguo Fan1, Qianyi Deng1,2

  • 1Institute of Stomatological Research, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510080, China.

Biomed Research International
|March 6, 2019
PubMed
Summary

Stem cells from the apical papilla (SCAPs) are a novel type of mesenchymal stem cell (MSC). These SCAPs show potential for various regenerative therapies, including dental and bone tissue repair.

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Area of Science:

  • * Regenerative Medicine
  • * Stem Cell Biology
  • * Dental Research

Background:

  • * Stem cell-based therapy offers promising treatment options for various disorders.
  • * Mesenchymal stem cells (MSCs) are multipotent adult stem cells used as an alternative to embryonic stem cells.
  • * Stem cells from the apical papilla (SCAPs) are a newly identified MSC population found in immature teeth.

Purpose of the Study:

  • * To review current knowledge on SCAPs, focusing on their isolation, characterization, and differentiation potential.
  • * To discuss the therapeutic prospects of SCAPs in various regenerative applications.
  • * To highlight SCAPs as candidates for stem cell-based therapies.

Main Methods:

  • * Literature review summarizing existing research on SCAPs.
  • * Analysis of SCAP characteristics, including marker expression, self-renewal, proliferation, migration, and differentiation capabilities.
  • * Evaluation of SCAP immunosuppressive properties.

Main Results:

  • * SCAPs express MSC markers and possess self-renewal and proliferation capabilities.
  • * SCAPs demonstrate multipotent differentiation into various cell lineages.
  • * SCAPs exhibit migration and immunosuppressive properties, crucial for therapeutic applications.

Conclusions:

  • * SCAPs possess characteristics suitable for stem cell-based therapy.
  • * SCAPs show significant potential for the regeneration of dental, bone, neural, and vascular tissues.
  • * SCAPs are promising candidates for immunotherapy and regenerative medicine.