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Related Concept Videos

Clinical Trials01:16

Clinical Trials

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Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
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Nursing Clinical Information System01:27

Nursing Clinical Information System

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Nursing Clinical Information System (NCIS)
A Nursing Clinical Information System (NCIS) is a specialized type of healthcare information system tailored to meet the unique needs of nursing practice. It incorporates the principles of nursing informatics to streamline information management and improve the quality of care delivery.
Critical attributes of NCIS include:
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Clinical Trials: Overview01:11

Clinical Trials: Overview

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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

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Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
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Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
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Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

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Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
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Related Experiment Video

Updated: Jan 28, 2026

Orthotopic Aortic Transplantation: A Rat Model to Study the Development of Chronic Vasculopathy
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Orthotopic Aortic Transplantation: A Rat Model to Study the Development of Chronic Vasculopathy

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Polypoidal choroidal vasculopathy: a comprehensive clinical update.

Atul Kumar1, Devesh Kumawat1, Dheepak Sundar M1

  • 1Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Therapeutic Advances in Ophthalmology
|March 6, 2019
PubMed
Summary
This summary is machine-generated.

Polypoidal choroidal vasculopathy presents unique challenges in diagnosis and management. This review clarifies its features, diagnostic methods like indocyanine angiography, and treatment options for better understanding.

Keywords:
afliberceptindocyanine green angiographyoptical coherence tomography angiographyphotodynamic therapypolypoidal choroidal vascuolpathypolypssubmacular haemorrhage

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Vascular Biology

Background:

  • Polypoidal choroidal vasculopathy (PCV) is incompletely understood.
  • Its clinical signs, including large serosanguineous detachments, can mimic neovascular age-related macular degeneration.
  • Diagnostic modalities and management strategies for PCV require further elucidation.

Purpose of the Study:

  • To provide a comprehensive review of polypoidal choroidal vasculopathy.
  • To clarify diagnostic challenges posed by various investigative modalities.
  • To elucidate current management strategies for PCV.

Main Methods:

  • Review of existing literature on polypoidal choroidal vasculopathy.
  • Analysis of clinical features and diagnostic imaging techniques.
  • Evaluation of current therapeutic approaches.

Main Results:

  • Polypoidal choroidal vasculopathy exhibits distinct clinical features that can be confused with other macular diseases.
  • Indocyanine angiography and optical coherence tomography angiography present specific diagnostic challenges.
  • A range of management strategies exist, but clarity on optimal approaches is limited.

Conclusions:

  • Enhanced understanding of PCV clinical presentation is crucial for accurate diagnosis.
  • Advanced imaging techniques aid in PCV diagnosis but require expertise.
  • Further research is needed to refine and standardize PCV management strategies.