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Updated: Jan 28, 2026

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Published on: June 10, 2013
Mood instability during pregnancy and postpartum: a systematic review
Hua Li1, Angela Bowen2, Rudy Bowen3
1College of Nursing, University of Saskatchewan, Health Sciences Building, E-Wing, Room 4248, 104 Clinic Place, Saskatoon, SK, S7N 2Z4, Canada. hua.li@usask.ca.
Perinatal mood instability (MI) is common in pregnant women and linked to mental health issues. This review highlights MI
Area of Science:
- Perinatal mental health
- Mood instability
- Maternal-infant interaction
Background:
- Perinatal mood instability (MI) is frequently observed in women during pregnancy and postpartum.
- Existing research links perinatal MI to various mental health disorders.
- Understanding the scope and impact of perinatal MI is crucial for maternal and child well-being.
Purpose of the Study:
- To systematically review the existing evidence on perinatal mood instability (MI).
- To focus on the relationship between perinatal MI and perinatal depression.
- To examine the effects of perinatal MI on children.
Main Methods:
- Systematic literature search adhering to PRISMA guidelines.
- Searched seven academic health databases for English-language, peer-reviewed articles (1985-July 2017).
- Screened 1927 abstracts, with 4 quantitative studies selected for final analysis after quality assessment.
Main Results:
- Perinatal women exhibited significantly higher levels of MI compared to non-perinatal women.
- MI is a notable characteristic in perinatal women, irrespective of depression status.
- Postpartum mood lability predicts psychopathology up to 14 months; maternal emotion dysregulation, not psychopathology, heightens mother-infant facial synchrony.
Conclusions:
- Perinatal mood instability is a significant clinical observation with implications for maternal mental health.
- The findings underscore the need for further research into perinatal MI and its long-term effects.
- A notable gap exists in the current literature regarding perinatal mood instability.
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