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|March 6, 2019
PubMed
Summary

This study introduces a new device for simultaneous ion mobility (IM) separation of positive and negative ions using radiofrequency fields. Initial results show comparable performance to single-polarity methods, enabling dual polarity ion confinement.

Keywords:
Dual polarity mass spectrometryIon mobilitySLIMStructures for lossless ion manipulations

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Area of Science:

  • Analytical Chemistry
  • Physical Chemistry

Background:

  • Structures for Lossless Ion Manipulations (SLIM) traditionally use DC fields for ion confinement.
  • Separating ions of opposite polarity simultaneously presents challenges in confinement and manipulation.

Purpose of the Study:

  • To implement and simulate a SLIM device capable of simultaneous ion mobility separation for both positive and negative ions.
  • To investigate the use of RF fields for dual polarity ion confinement and explore its impact on separation performance.

Main Methods:

  • Simulations of ion trajectories within the SLIM device.
  • Initial experimental implementation of the dual-polarity SLIM device.
  • Utilizing traveling wave (TW) voltage profiles for ion transport and separation.
  • Employing RF fields instead of DC fields for lateral ion confinement.

Main Results:

  • Successful demonstration of simultaneous ion mobility separation for positive and negative ions within the same SLIM path.
  • RF fields effectively confine ions of opposite polarities, replacing traditional DC fields.
  • Ion trajectory simulations indicate potential for spatial manipulation of ion populations to minimize ion interactions.
  • Achieved IM performance comparable to previous single-polarity SLIM separations.

Conclusions:

  • The developed SLIM device enables simultaneous separation of cations and anions, expanding the capabilities of ion mobility spectrometry.
  • RF field-based confinement offers a viable alternative for dual-polarity ion manipulation in SLIM devices.
  • Further optimization of RF and TW potentials can enhance ion separation and reduce cross-polarity interactions.