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Updated: Jan 28, 2026

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis
Published on: March 14, 2025
Pediatric toxic epidermal necrolysis treated successfully with infliximab
Lana Chafranska1,2, Ditte M Saunte1,2, Nille Behrendt2,3
1Departments of Dermatology, Zealand University Hospital, Roskilde, Denmark.
Abstract:
Successful management of toxic epidermal necrolysis (TEN) with tumor necrosis factor-α inhibitors has been described in adults. We present a case of a 7-year-old boy with infection-associated TEN, diagnosed by typical clinical and histopathological features, most likely caused by Mycoplasma pneumoniae. Treatment with a single dose of infliximab 5 mg/kg intravenously on day 5 after the onset of symptoms was followed by cessation of all blister formation over 3 days and complete resolution within a week. Sequelae were mild, consisting of postinflammatory hyperpigmentation and dry eyes.
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