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How Cancer Cells Resist Chemotherapy: Design and Development of Drugs Targeting Protein-Protein Interactions

Vadim V Tarasov1, Vladimir N Chubarev1, Ghulam Md Ashraf2

  • 1Sechenov First Moscow State Medical University (Sechenov University), 8-2 Trubetskaya St., Moscow 119991, Russian Federation.

Current Topics in Medicinal Chemistry
|March 6, 2019
PubMed
Abstract

Insights

Identifying reliable cancer drug resistance markers is crucial for personalized chemotherapy. This study reviews resistance mechanisms and proposes a study design to find effective biomarkers for improved cancer treatment outcomes.

Area of Science:

  • Oncology
  • Pharmacology
  • Biomarker Discovery

Background:

  • Chemotherapeutic resistance is a major challenge in cancer treatment.
  • Personalized chemotherapy offers potential for improved clinical outcomes.
  • Many potential biomarkers fail clinical translation due to inadequate impact assessment.

Purpose of the Study:

  • Analyze drug resistance mechanisms in cancer cells.
  • Propose a study design to identify reliable biomarkers for drug resistance.

Main Methods:

  • Literature review of relevant scientific papers.
  • PubMed search using keywords such as 'drug resistance', 'cancer', and 'paclitaxel'.

Main Results:

  • Cataloged various drug resistance mechanisms and associated markers.
  • Developed a rational study design model for identifying promising biomarkers.

Conclusions:

  • Utilizing appropriate biomarkers can significantly enhance treatment efficacy.
  • Further research is needed to determine leading biomarkers and validate the proposed study design.
Keywords:
BiomarkersCancerChemotherapyDrug resistanceOncological diseasesProtein-protein interaction.

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