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Updated: Jan 26, 2026

Purification of Platelets from Mouse Blood
Published on: May 7, 2019
The in vitro effect of amrinone on platelet aggregation in human whole blood
Abstract:
Amrinone was found to inhibit platelet aggregation in human whole blood in a dose dependent manner, and at physiological levels of the drug. Statistically significant drug-related decreases in aggregation were observed with collagen, ADP and arachidonic acid. Inhibition of aggregation was most marked with arachidonic acid, where greater than 90% inhibition was achieved at a drug concentration of 25 mugml-1. The aggregation profiles presented indicate that amrinone inhibits aggregation primarily through inhibition of thromboxane A2 synthesis.
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