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Updated: Jan 28, 2026
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Ischemia-reperfusion Model of Acute Kidney Injury and Post Injury Fibrosis in Mice
Published on: August 9, 2013
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[Perioperative acute kidney injury]
1Klinik für Anästhesiologie, operative Intensivmedizin und Schmerztherapie, Universitätsklinikum Münster, Albert-Schweitzer-Campus 1, Gebäude A1, 48149, Münster, Deutschland.
Der Anaesthesist
|March 6, 2019
Summary
Early detection and prevention are crucial for perioperative acute kidney injury (AKI). Implementing Kidney Disease: Improving Global Outcome (KDIGO) guidelines and bundles significantly reduces AKI incidence in high-risk patients.
Area of Science:
- Nephrology
- Perioperative Medicine
- Critical Care
Background:
- Acute kidney injury (AKI) is a common and serious complication in the perioperative period, linked to increased morbidity and mortality.
- AKI serves as an independent risk factor for adverse patient outcomes.
- Current definitions of AKI rely on serum creatinine and/or urine output changes, with no specific causal therapy available.
Purpose of the Study:
- To provide an overview of perioperative AKI.
- To present recommendations for the diagnosis, prevention, and treatment of perioperative AKI.
- To summarize current evidence-based strategies for managing AKI.
Main Methods:
- Literature review summarizing available evidence.
- Analysis of current diagnostic criteria and therapeutic approaches.
- Evaluation of preventive measures and their efficacy.
Main Results:
- Novel renal biomarkers enable early prediction of AKI development.
- Implementation of KDIGO bundles (e.g., medication review, hemodynamic optimization, monitoring) significantly reduces AKI incidence.
- Remote ischemic preconditioning shows promise in mitigating AKI in high-risk individuals.
Conclusions:
- Adherence to KDIGO guidelines is essential for timely AKI diagnosis and prevention.
- Early identification of high-risk patients allows for proactive implementation of preventive strategies.
- A multi-faceted approach combining monitoring, guideline adherence, and specific interventions is key to managing perioperative AKI.
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