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CGRP and headache: a brief review.

Stewart J Tepper1,2

  • 1Neurology Department, Dartmouth-Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH, 03756, USA. Stewart.J.Tepper@Dartmouth.edu.

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
|March 6, 2019
PubMed
Summary

New anti-CGRP medications, including monoclonal antibodies (mAbs), offer effective migraine prevention. These treatments show rapid, well-tolerated results, even in patients with prior treatment failures.

Keywords:
CGRPCalcitonin gene-related peptideGepantsMigraineMonoclonal antibodies

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Area of Science:

  • Neurology
  • Pharmacology
  • Translational Research

Background:

  • Migraine treatment has historically faced challenges with efficacy and tolerability.
  • Calcitonin gene-related peptide (CGRP) pathway is a key target for migraine pathophysiology.

Purpose of the Study:

  • To evaluate the impact and efficacy of anti-CGRP monoclonal antibody (mAb) therapeutics in migraine prevention.
  • To highlight the significance of translational research in developing novel migraine treatments.

Main Methods:

  • Review of clinical data and outcomes for anti-CGRP monoclonal antibody therapies.
  • Analysis of treatment response rates, tolerability, and safety profiles compared to placebo.

Main Results:

  • Anti-CGRP mAbs demonstrate rapid efficacy, with significant separation from placebo within weeks.
  • High responder rates (≥75%) and excellent tolerability, similar to placebo, were observed.
  • These therapies effectively reduce acute medication use and can convert chronic migraine to episodic migraine.

Conclusions:

  • Anti-CGRP monoclonal antibodies represent a significant advancement in migraine prevention.
  • These targeted therapies offer a well-tolerated and highly effective treatment option for diverse migraine populations.
  • The widespread adoption of anti-CGRP mAbs is transforming migraine management globally.