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Transarterial Administration of Oncolytic Viruses for Locoregional Therapy of Orthotopic HCC in Rats
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HCC: Transarterial Therapies-What the Interventional Radiologist Can Offer

Thomas J Vogl1, Tatjana Gruber-Rouh2

  • 1Institute for Diagnostic and Interventional Radiology, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany. T.Vogl@em.uni-frankfurt.de.

Digestive Diseases and Sciences
|March 6, 2019
PubMed

Insights

Effective treatments for advanced hepatocellular carcinoma (HCC) are crucial due to rising incidence and mortality. Interventional radiologists offer key regional, intraarterial therapies for HCC management.

Area of Science:

  • Oncology
  • Interventional Radiology

Background:

  • Hepatocellular carcinoma (HCC) incidence and mortality rates are increasing globally.
  • Effective multidisciplinary treatment strategies for advanced-stage HCC are urgently required.

Purpose of the Study:

  • To review current literature on regional, intraarterial treatment strategies for advanced-stage HCC.
  • To highlight the role of interventional radiologists in managing HCC patients.

Main Methods:

  • Literature review of regional, intraarterial therapies for advanced HCC.
  • Focused on transarterial chemoembolization, transarterial embolization, drug-eluting bead transarterial embolization, and selective internal radiation therapy.

Main Results:

  • The review covers established and evolving intraarterial treatment modalities for advanced HCC.
  • These therapies offer regional control for patients with advanced disease.

Conclusions:

  • Interventional radiology provides essential minimally invasive treatment options for advanced HCC.
  • Further research and integration of these techniques in multidisciplinary care are warranted.

Keywords:
Conventional transarterial chemoembolization (cTACE)Drugeluting bead TACE (DEB-TACE)Hepatocellular carcinoma (HCC)Selective internal radiation therapy (SIRT)

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