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Updated: Jan 28, 2026
Author Spotlight: Repetitive Transcranial Magnetic Stimulation Combined with Movement Observation in Cerebral Palsy
Published on: August 9, 2024
[Genetic analysis of 10 children with cerebral palsy]
Qingwen Zhu1, Yufei Ni, Jing Wang
1Nantong Maternal and Child Health Care Hospital, Nantong, Jiangsu 210036, China. 87183653@qq.com.
Objective:
To explore the genetic basis of cerebral palsy (CP).
Methods:
A pair of twins with cerebral palsy and different phenotypes were subjected to whole genome sequencing, and other 8 children with CP were subjected to whole exome sequencing. Genetic variations were screened by a self-designed filtration process in order to explore the CP-related biological pathways and genes.
Results:
Three biological pathways related to CP were identified, which included axon guiding, transmission across chemical synapses and protein-protein interactions at synapses, and 25 susceptibility genes for CP were identified.
Conclusion:
The molecular mechanism of CP has been explored, which may provide clues for development of new treatment for CP.
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