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Prognostic efficacy of C-reactive protein/albumin ratio in ST elevation myocardial infarction

Tufan Çınar1, Metin Çağdaş2, İbrahim Rencüzoğulları2

  • 1a Department of Cardiology , Health Sciences University, Sultan Abdülhamid Han Training and Research Hospital , Istanbul , Turkey.

Scandinavian Cardiovascular Journal : SCJ
|March 6, 2019
PubMed

Insights

The C-reactive protein/Albumin ratio (CAR) can predict poor prognosis in ST-elevation myocardial infarction (STEMI) patients. This inflammation-based index showed superior prognostic performance compared to other markers.

Area of Science:

  • Cardiology
  • Biomarkers
  • Inflammation

Background:

  • C-reactive protein and albumin levels are known prognostic markers in ST-elevation myocardial infarction (STEMI).
  • The prognostic value of the C-reactive protein/Albumin ratio (CAR) in STEMI has not been previously investigated.

Purpose of the Study:

  • To investigate the prognostic efficacy of the CAR in predicting outcomes for patients with STEMI.
  • To evaluate the CAR as a potential risk index for STEMI prognosis.

Main Methods:

  • A cohort of 2243 patients with first STEMI, treated with primary percutaneous coronary intervention, was analyzed.
  • Patients were stratified into three groups based on CAR tertiles.
  • Kaplan-Meier survival analysis and receiver operating characteristic (ROC) curve analysis were performed.

Main Results:

  • Higher CAR tertiles were associated with significantly lower in-hospital and long-term survival rates.
  • The CAR was identified as an independent predictor of all-cause mortality (HR: 1.033, p=0.033).
  • The CAR demonstrated superior prognostic performance compared to C-reactive protein, albumin, and neutrophil-to-lymphocyte ratio in ROC analysis.

Conclusions:

  • The CAR is a novel inflammation-based index with potential utility in predicting poor prognosis in STEMI patients.
  • The CAR may serve as a valuable prognostic tool for STEMI management.
  • Further validation in prospective studies is warranted to confirm these findings.
Abstract

Keywords:
C-reactive protein to Albumin ratioST elevation myocardial infarctionall-cause mortality

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