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Updated: Jan 28, 2026
08:46
A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
Published on: August 12, 2020
6.9K
Evaluation of myocardial function in neonatal sepsis using tissue Doppler imaging
Sameh S Fahmey1, Mahmoud Hodeib1, Khaled Refaat2
1Pediatrics Department, Beni-Suef University, Beni Suef, Egypt.
Summary
Neonatal sepsis impairs cardiac function, causing diastolic dysfunction and higher pulmonary pressure. Reduced left ventricular function in septic neonates indicates a poor prognosis.
Area of Science:
- Neonatal cardiology
- Pediatric critical care medicine
- Echocardiography
Background:
- Neonatal sepsis is a leading cause of infant mortality, particularly in developing nations.
- Cardiac dysfunction is a critical complication of severe sepsis, contributing to multi-organ failure.
Purpose of the Study:
- To evaluate right and left ventricular functions in neonates diagnosed with sepsis.
- Utilize tissue Doppler imaging (TDI) to assess myocardial performance in septic neonates.
Main Methods:
- Enrolled 50 septic neonates and 25 healthy controls for echocardiographic assessment.
- Employed conventional echocardiography and tissue Doppler imaging (TDI) to measure myocardial function and pulmonary systolic pressure.
Main Results:
- Septic neonates exhibited lower mitral valve E/A ratios, signifying left ventricular diastolic dysfunction.
- Significantly elevated pulmonary systolic pressure was observed in septic neonates compared to controls.
- Left ventricular systolic function did not differ significantly, but reduced left ventricular fractional shortening (LVFS) correlated with mortality.
Conclusions:
- Neonates with sepsis demonstrate left ventricular diastolic dysfunction and increased pulmonary systolic pressure.
- Diminished left ventricular fractional shortening (LVFS) in septic neonates is linked to adverse outcomes and poor prognosis.
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