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Published on: June 12, 2017
Initial clinical application of tissue pH neutralization after esophageal button battery removal in children
Kris R Jatana1, Christine L Barron2, Ian N Jacobs3,4
1Department of Otolaryngology-Head and Neck Surgery, Nationwide Children's Hospital and Wexner Medical Center at Ohio State University, Columbus, Ohio.
Insights
Acetic acid irrigation after pediatric button battery removal safely neutralizes esophageal pH, improving tissue appearance and preventing perforation or strictures. This technique is recommended for managing these serious injuries.
Area of Science:
- Pediatric Gastroenterology
- Otolaryngology
- Emergency Medicine
Background:
- Pediatric esophageal button battery (BB) injuries pose significant risks, including ongoing morbidity and mortality even after removal.
- The alkaline environment created by BBs can lead to progressive tissue damage.
Purpose of the Study:
- To evaluate the safety and efficacy of intraoperative tissue pH neutralization using 0.25% acetic acid irrigation following BB removal in pediatric patients.
- To present initial safety data for this novel application.
Main Methods:
- A retrospective case series involving pediatric patients who underwent rigid esophagoscopy for BB removal.
- Irrigation of the esophageal injury site with 120-150 mL of sterile 0.25% acetic acid (pH 3) after BB removal.
- Assessment of visual tissue appearance, esophageal perforation, and stricture formation.
Main Results:
- Six pediatric patients with esophageal BBs removed after 2-18 hours were treated.
- No patients exhibited thermal tissue injury post-irrigation.
- All patients demonstrated improved visual esophageal tissue appearance.
- No immediate or delayed esophageal perforations or strictures were observed.
Conclusions:
- Intraoperative esophageal irrigation with 0.25% acetic acid is safe and effective in neutralizing the alkaline tissue microenvironment after BB removal.
- This pH neutralization improves mucosal appearance and may prevent further liquefactive necrosis.
- The technique aligns with current National Capital Poison Center guidelines for BB injury management.
Objectives/Hypothesis:
Pediatric esophageal button battery (BB) injuries can progress even after removal and continue to be a significant source of morbidity and mortality. The objective in this case series is to present initial safety data for the human application of intraoperative tissue pH neutralization using 0.25% acetic acid irrigation after BB removal.
Study Design:
Retrospective case series.
Methods:
Pediatric patients who underwent rigid esophagoscopy for BB removal between October 2016 and December 2017 and who had the injury site irrigated with 120 to 150 mL sterile 0.25% acetic acid (pH = 3) were included in the study. Outcome measures included visual tissue appearance after irrigation, immediate or delayed esophageal perforation, and evidence of eventual esophageal stricture formation.
Results:
Six pediatric patients (aged 19 months-10 years) had a 3 V lithium BB lodged in the esophagus for 2 to 18 hours and had irrigation of the esophageal injury site with sterile 0.25% acetic acid in the operating room after BB removal. None of the patients showed any evidence of thermal tissue injury. By surgeon assessment, all cases had improved visual esophageal tissue appearance. Neither immediate post-operative or delayed onset esophageal perforation nor eventual stricture development were seen.
Conclusions:
Esophageal irrigation in the operating room with sterile 0.25% acetic acid after BB removal, to neutralize the highly alkaline tissue microenvironment (pH 10-13) was safe and resulted in improved visual mucosal appearance. This immediate tissue pH neutralization may help halt the progression of liquefactive necrosis by immediately bringing tissue pH to physiologic range. This post-removal irrigation technique is recommended by current National Capital Poison Center BB guidelines.
Level Of Evidence:
4 Laryngoscope, 129:1772-1776, 2019.
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