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Aspiration in the otherwise healthy Infant-Is there a natural course for improvement?
Geoffrey C Casazza1,2, M Elise Graham1,2, Fadi Asfour3,2
1Division of Pediatric Otolaryngology-Head and Neck Surgery, University of Utah, Salt Lake City, Utah, U.S.A.
Insights
Most infants with aspiration, a swallowing dysfunction, improve within one year without surgery. This study highlights the natural course of recovery in healthy infants, suggesting further research into neurologically normal infant swallowing.
Area of Science:
- Pediatric Gastroenterology
- Otolaryngology
- Speech-Language Pathology
Background:
- Pediatric oropharyngeal dysphagia management, particularly surgical intervention timing, presents significant challenges.
- Limited research exists on the natural progression of swallowing dysfunction in otherwise healthy infants.
Purpose of the Study:
- To evaluate the outcomes and time to resolution of abnormal swallowing in infants diagnosed with aspiration.
- To understand the natural course of swallowing dysfunction in infants without significant comorbidities.
Main Methods:
- A retrospective case series was conducted at a tertiary children's hospital.
- Fifty infants under one year old with aspiration on a modified barium swallow study were included.
- Exclusion criteria included prematurity (<34 weeks), medical/genetic comorbidities, or prior surgical intervention for aspiration. Patients were followed until aspiration resolved.
Main Results:
- Forty out of fifty patients (80%) achieved resolution of aspiration.
- The median time to resolution was 202 days (range: 19-842 days).
- Resolution probabilities were 46% at 6 months, 64% at 1 year, 76% at 2 years, and 81.3% by the end of follow-up.
Conclusions:
- The majority of infants with aspiration and no major comorbidities experience improvement within one year.
- Further research is needed to better understand swallowing dysfunction in neurologically normal infants.
- This study provides insights into the natural resolution of aspiration in infants, informing clinical management decisions.
Objectives/Hypothesis:
Timing and indication for surgical intervention is a major challenge in managing pediatric oropharyngeal dysphagia. No study has evaluated a natural course of swallowing dysfunction in otherwise healthy infants. Our objective was to review the outcomes and time to resolution of abnormal swallow in infants with aspiration.
Study Design:
Retrospective case series at a tertiary children's hospital.
Methods:
Fifty patients under 1 year old with aspiration on a modified barium swallow study were included. Patients born <34 weeks, with medical or genetic comorbidities, or who underwent surgical intervention for aspiration were excluded. Patients were followed until aspiration resolved on a swallow study. Kaplan-Meier survival analysis was performed.
Results:
Forty patients (25 patients [50%] by 6 months, 10 [20%] by 1 year, three [6%] by 2 years, and two [4%] at the end of the follow-up interval) were recommended a normal diet, and 10 patients (20%) were still aspirating by the end of the follow-up interval. Median time to resolution was 202 ± 7 days (range, 19-842 days), probability 48% (95% confidence interval [CI]: 0.34-0.62). The probability of resolution at 6 months was 46% (95% CI: 0.4-0.68), at 1 year was 64% (95% CI: 0.51-0.77), at 2 years was 76% (95% CI: 0.64-0.88), and at the end of the follow-up interval 81.3% (95% CI: 0.7-0.92).
Conclusions:
The majority of infants with aspiration and without any other major comorbidities improved within 1 year. Future research should be directed toward better understanding swallowing dysfunction in neurologically normal infants.
Level Of Evidence:
4 Laryngoscope, 130:514-520, 2020.
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